Dr. Su Yang is currently a professor of Guangdong-HongKong-Macau Institute of CNS Regeneration (GHMICR) at Jinan University. He got his bachelor’s degree from Nanjing University in 2008, and his Ph.D. degree from Emory University in 2014. From 2014 to 2019, he performed his postdoctoral research in Dr. Xiao-Jiang Li’s lab in the Department of Human Genetics at Emory University. He joined GHMICR in the March of 2019. Dr. Su Yang’s research is focused on elucidating the pathogenic mechanisms of neurodegenerative diseases and developing CRISPR-based therapeutic approaches. Another research focus is to explore the function of mesencephalic astrocyte-derived neurotrophic factor (MANF) in the central nervous system. He has published more than 20 papers on high impact journals, including Neuron, Journal of Clinical Investigation, Nature Communications, PNAS and Cell Reports. He is the recipient of the Professional Development Award from Society for Neuroscience. His current research is supported by funding from National Natural Science Foundation of China and Department of Science and Technology of Guangdong Province.
1. Yang, S., Huang, S., Gaertig, M.A., Li, X.J., and Li, S. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. （first author)
Neuron, 2014 Jan 22;81(2):349-65. IF:15.054
2. Yang, S.*, Chang, R.*, Yang, H., Zhao, T., Hong, Y., Kong, H., Sun, X., Qin, Z., Jin, P., Li, S., and Li, X.J. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease. (* co-first author)
Journal of Clinical Investigation, 2017 Jun 30;127(7):2719-2724. IF:13.251
3. Yang, S.#, Yang, H., Chang, R., Yin, P., Yang, Y., Yang, W., Huang, S., Gaertig, M.A., Li, S.#, and Li, X.J.# MANF regulates hypothalamic control of food intake and body weight. (first author，#co-corresponding author)
Nature Communications, 2017 Sep 18;8(1):579. IF:12.353
4. Yang, S.*,#, Yang, H.*, Huang, L., Chen, L., Qin, Z., Li, S., and Li, X.J.#Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice. (* co-first author，# co-corresponding author)
PNAS，2020 Feb 25;117(8):4411-4417. IF:9.412
5. Yang, S.#, Li, S., and Li, X.J.# Shortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity. (#co-corresponding author)
Cell Reports, 2018 Dec 4;25(10):2653-2659.e3. IF:7.87
6. Huang, S.*, Yang. S.*, Guo, J., Yan. S., Gaertig, M.A., Li, S. and Li, X.J. Large polyglutamine repeats cause muscle degeneration in SCA17 mice. (* co-first author)
Cell Reports, 2015 Oct 6;13(1):196-208.IF:7.87
7. Yang, Y.*, Yang, S.*, Guo, J., Cui, Y., Tang, B., Li, X.J., and Li, S.Synergistic toxicity of polyglutamine-expanded TBP in glia and neuronal cells: therapeutic implications for SCA17.(* co-first author)
Journal of Neuroscience, 2017 Sep 20;37(38):9101-9115. IF:5.971
8. Guo, J., Cui, Y., Yang, Y., Li, Y., Weng, L., Tang, B., Jin, P., Li, X.J., Yang, S.#, and Li, S.# Piperine ameliorates SCA17 neuropathology via enhancing MANF expression and reducing ER stress. (#co-corresponding author)
Molecular Neurodegeneration, 2018 Jan 30;13(1):4. IF:6.426
