Dr. Qu is currently an Associate Professor of the GHMICR Institute. She got her bachelor’s degree from Tsinghua University in 2006 and Ph.D. from University of Louvain in 2011. Dr. Qu’s research is focused on the role of Planar Cell Polarity proteins in brain development. She has series publications on peer-viewed journals including Nature Neuroscience, PNAS, Cerebral Cortex, Journal of Neuroscience. Wiring of axonal projections and cortical dendrites is critical to neural and cognitive function. We know that planar cell polarity (PCP) genes Celsr3 and Fzd3 are crucial for forebrain wiring in vivo and that Celsr2 and Celsr3 control dendrite growth in vitro. Since PCP genes are so important, the focus of their research is to understand further their functions during forebrain development in GHMICR Institute.
1. Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y* and Zhou L* (2016). Celsr3 and Fzd3 organize a pioneer neuron scaffold to steer growing thalamocortical axons. Cerebral Cortex. 26(7): 3323-34.
2. Han Qi，Cao Changshu，Ding yuetong，So Kwok-Fai，Wu Wutian，Qu Yibo*，Zhou Libing*. (2015) Plasticity of motor networks and function in the congenital absence of corticospinal projections. Experimental Neurology, 267:194-208.
3. Hunag, Liting, Xian, Quanxiang, Sheng, Ning, Shi, Lingling, Qu Yibo*，Zhou Libing*. (2015) Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord. Neuroscience, 301:338-350.
4.Qu Yibo, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM. （2014）Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A (PNAS), 111(29):E2996-3004.
5. Tissir F*, Qu Yibo*, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nature Neuroscience. 13(6):700-7.
6. Qu Yibo*, Glasco DM*, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. Journal of Neuroscience, 30(28):9392-401.
