-
2024.01 24
Researchers at Jinan University visualize direct glia-to-neuron conversion in situ with two-photon live imaging
Neurodegenerative diseases have become an increasingly serious societal problem worldwide as population aging continues. Since nerve cells in the central nervous system cannot regenerate themselves, nerve damage is often irreversible and permanent. So far, disease-modifying treatment is rarely available for most of the neurodegenerative diseases. A new technology called in situglia-to-neuron conversion technology emerges as a potential game-changer for the treatment of neurodegenerative diseas
-
2022.04 02
New study deciphers the circuit mechanisms of the antinociceptive effects of bright light
Prof. Chaoran Ren`s group published an article entitled `A visual circuit related to the periaqueductal gray area for the antinociceptive effects of bright light treatment` in the latest issue of Neuron. They identified a visual circuit related to the periaqueductal gray (PAG) which underlies the antinociceptive effects of bright light treatment. Light is a powerful modulator of non-image-forming functions, including mood, cognition, and pain. Prof. Ren`s team endeavors to endeavors to elucida
-
2021.12 31
Neuroregenerative Gene Therapy Treats Temporal Lobe Epilepsy in Rat Model
A research team led by Professor Gong Chen of Jinan University in Guangzhou, China, published an article in the latest issue of Progress in Neurobiology, using neuroregenerative gene therapy to treat temporal lobe epilepsy (TLE) in rats. Chen’s team developed a new technology to convert hippocampal astrocytes directly into inhibitory interneurons and effectively reduced epileptic seizures, raising new hope for patients suffering from refractory TLE.There are about 50 million epileptic patients w
-
2021.11 23
Polysaccharides derived from berries spark interest
Compounds from goji berries may have neuroprotective effects for retinal cells and implications for subthreshold depression, early research suggests. The researchers involved say the findings should prompt more thorough investigations of this and thousands of other traditional Chinese medicine derived compounds.Goji berries, also known as wolfberries, are listed in the ancientChinesebookTheClassic of Herbal Medicine as having benefits to the eyes, explains Kwok-Fai So, director of the Guangdong-
-
2020.12 18
First Non-human primate study showing promise of neuroregenerative gene therapy for stroke repair
First Non-human primate study showing promise of neuroregenerative gene therapy for stroke repair Stroke is a leading cause of death and severe long-term disability with limited treatment available. A research team led by Prof. Gong Chenat Jinan University, Guangzhou, China recently reported the first non-human primate study demonstrating successful in vivoneural regeneration from brain internal glial cells for stroke repair. This work was published on Frontiers in Cell and Developmental Biolog
-
2020.12 18
Neuroregenerative Gene Therapy Brings New Hope to Patients with Spinal Cord Injury
Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies. One of the major reasons for the difficulty of treatment for SCI might be due to the fact that many neurons are lost during the injury, leading to permanent loss of neural functions. In the current issue of Frontiers in Cell and Development
-
2020.10 14
Reversal of Glial Scar Tissue Back to Neuronal Tissue Through Neuroregenerative Gene Therapy
Brain or spinal cord injury often results in glial scar tissue that is correlated to neural functional loss. Glial scar is a well-known obstacle for neural regeneration due to its dense glial cell composition and lack of functional neurons. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, China, published an article on November 5th, 2020 in the current issue of Frontiers in Cellular Neuroscience, demonstrating that glial scar tissue can be reversed back to neuronal tissue
