Dr. Xu is currently a research Professor of the GHM Institute of CNS Regeneration. She got her bachelor’s degree from Peking University in 1997 and Ph.D. from Chinese Academy of Science in 2002. Then she spent more than 7 years working in University of Pennsylvania of US as a postdoctoral researcher and later research associate. In Dec, 2009, she joined Jinan University as a faculty. Dr. Xu’s research was focused on the mechanism of visual responses of neurons in mammalian visual system, mainly by electrophysiological recording, both in-vivo and in-vitro. After she set up her lab in Jinan University, she started working on the treatment of retinal degenerative diseases by mainly electrophysiological recording, immunofluorescent imaging, biochemical and behavioral test. She has series publications on peer-viewed journals including Journal of Neuroscience, Journal of Neurochemistry, IOVS, Neuropharmacology etc. She has multiple grants support from National Basic Research Program of China (973 Program), National Natural Science Foundation of China and Guangdong Province.
1. Liu F, Zhang J, Xiang Z, Xu D, So KF, Vardi N, Xu Y*. Lycium barbarum polysaccharides protect retina in rd1 mice during photoreceptors degeneration. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):597-611.
2. Zhang J, Xu D, Ouyang H, Hu S, Li A, Luo H*, Xu Y*.Neuroprotective effects of methyl 3,4 dihydroxybenzoate in a mouse model of retinitis pigmentosa. Exp Eye Res. 2017 Sep;162:86-96.
3. Luo X, Yu Y, Xiang Z, Wu H, Ramakrishna S, Wang Y, So KF, Zhang Z*, Xu Y*. Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity. J Neurochem. 2017, 141(3):373-386. doi: 10.1111/jnc.13970.
4. Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y*, Zhou L*.Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells. IOVS, 2016 May 1;57(6):2788-96.
5. Xu Y*, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N*. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci Rep. 2016 Feb 17;6:20940.
6. Yang S, Luo X, Xiong G, So KF, Yang H, Xu Y. The electroretinogram of Mongolian gerbil (Meriones unguiculatus): Comparison to mouse. Neurosci Lett. 2015 Mar 4;589:7-12.
7. Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y*. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326
8. Sulaiman P, Xu Y, Fina ME, Tummala SR, Ramakrishnan H, Dhingra A, Vardi N.Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins. J Biol Chem. 2013 Mar 8;288(10):7420-9
9. Xu Y, Dhingra A, Fina ME, Koike C, Furukawa T, Vardi N. mGluR6 deletion renders the TRPM1 channel in retina inactive. J Neurophysiol. 2012 Feb;107(3):948-57. Epub 2011 Nov 30.
10. Xu Y, Xiao YM, Diao YC, So KF. Postnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamster. Neural Regen Res.2011,6(28):2165-2170.
11. Dhingra A, Ramakrishnan H, Neinstein A, Fina ME, Xu Y, Li J, Chung DC, Lyubarsky A, Vardi N. Gβ3 is required for normal light ON responses and synaptic maintenance. J Neurosci. 2012 Aug 15;32(33):11343-55.
12. Dhingra A, Fina ME, Neinstein A, Ramsey DJ, Xu Y, Fishman GA, Alexander KR, Qian H, Peachey NS, Gregg RG, Vardi N. Autoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells. J Neurosci. 2011 Mar 16;31(11):3962-7.
13. Xu Y, Sulaiman P, Feddersen RM, Liu J, Smith RG, Vardi N. Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response. J. Neurosci, 2008, 28(36): 8873-84.
14. Xu Y, Vasudeva V, Vardi N, Sterling P, Freed M. Different types of ganglion cell share a synaptic pattern. J Comp Neurol, . 2008, 507(6): 1871-1878.
