Xiangyu Guo, Ph.D., Associated Professor. Obtained Ph.D. degree at Kunming Institute of Zoology, Chinese Academy of Sciences in 2011. In 2012, Dr. Guo started his postdoctoral research work in Emory University, department of human genetics, then moved to Institute of Genetics and Developmental Biology, Chinese Academy of Sciences to continue his research. From graduate student stage, Dr. Guo began to focus on developmental and neural biology, participated in the accomplishment of Chinese first transgenic monkey, then joined in professor Xiao-Jiang Li lab, dedicating to create novel monkey model of neurodegenerative disease, using sophisticated technique such as CRISPR/Cas9. Dr. Guo took part in the work of creation of first transgenic Parkinson’s disease monkey model, first functional gene knockout monkey of DMD disease in the world, meanwhile his work also shred insight of disease molecular pathology. His work were published in journals of Cell Research, Human Molecular Genetics, Molecular Neurodegeneration， Journal of Neuroscience. Dr. Guo is experienced in technique development of making non-human primate disease model as well as molecular pathogenesis, Currently undertake one sub task of State's Key Project of Research and Development Plan, one Science and Technology Plan of Guangdong Province, applicating for 2 patents.
1. Z. Tu, W. Yang, S. Yan, A. Yin, J. Gao, X. Liu, Y. Zheng, J. Zheng, Z. Li, S. Yang, S. Li, X. Guo, X.J. Li, Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos, Sci Rep 7 (2017) 42081.
2. Tu Z, Yang W, Yan S, Guo X, Li X-J. CRISPR/Cas9: A powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases. Mol Neurodegener. 2015 Aug 4;10(1):35. (corresponding author )
3. Guo X, Li XJ . Targeted genome editing in primate embryos. Cell Res. 2015 Jul; 25(7):767-8.
