Dr. Yu Jiandong graduated from Beijing Normal University in 2003 and obtained his Ph.D. degree at Institute of Biophysics, Chinese Academy of Sciences. Dr. Yu did postdoctoral research at Rutgers University focused on interneuron function in epilepsy. He has received postdoc fellowship from Epilepsy Foundation. Dr. Yu joined Jinan University as associate professor, focusing on in vivo reprogramming in epilepsy.
Epilepsy is a disorder characterized by abnormal increases in network excitability, synchrony, and alterations in oscillatory rhythms. And epilepsy always accompany with abundant inhibitory GABAergic interneurons death. Our major research goal is to convert astrocytes into functional GABAergic interneurons in epileptic brain.1. Jiandong Yu, Bogumila Swietekb, Archana Prodduturb, Vijayalakshmi Santhakumar (2016). Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 89, 23-35.
2. Jiandong Yu, Archana Proddutur, Bogumila Swietek, Fatima S. Elgammal and Vijayalakshmi Santhakumar(2016). Functional reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms. Cerebral Cortex. 26(11): 4299-4314. （封面文章）
3. Jiandong Yu, Bogumila Swietek, Archana Proddutur, and Vijayalakshmi Santhakumar (2015). Dentate total molecular layer interneurons mediate cannabinoid-sensitive inhibition. Hippocampus. 25(8):884-9.
4. Archana Proddutur, Jiandong Yu, Fatima S. Elgammal, and Vijayalakshmi Santhakumar (2013) Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations. Chaos: An Interdisciplinary Journal of Nonlinear Science 23 (4), 046109. （封面文章）
5. Jiandong Yu*, Archana Proddutur*, Fatima S. Elgammal, Takahiro Ito, and Vijayalakshmi Santhakumar (2013) Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. J. Neurophysiology 109 (7), 1746-1763.(* Co-first author)
6. Jiandong Yu, Jinhui Wang (2012) Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Mol Brain. Aug 1; 5:26.
7. Jiandong Yu, Hao Qian, Na Chen, Jinhui Wang (2011) Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PLoS ONE. Sep 20; 6(9): e25219.
8. Na Chen, Jiandong Yu, Qian H, Ge R and Jinhui Wang (2010) Axons amplify somatic incomplete spikes into uniform amplitudes in mouse cortical pyramidal neurons. PLoS ONE. Jul 29; 5(7):e11868.
9. Jinhui Wang, Jian Wei, Xin Chen, Jiandong Yu, Na Chen, Jack Shi (2008) Gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding. J Cell Science 121(17) 2951-2960.
10. Na Chen, Xin Chen, Jiandong Yu and Jinhui Wang (2006) Afterhyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels. Biochemical and Biophysical Research Communications, 346(3), 938-945.
