Shi Lingling obtained M.D. and Ph.D. degree from Jinan University School of Medicine. She did postdoctoral training on human genomics at the University of Southern California, USA. Dr. Shi’s current research interests include: 1. Investigate the functional genetic link of targeted gene difficient and neurodevelopment in induced ploripotent stem cell derived neural stem cell models or transgenic mice, to find out why genetic mutations in some synaptic genes, including point mutations and copy number variants (CNVs), predispose to neurodevelopmental disorders such as autism and schizophrenia. 2. Application of Next-Generation Sequencing (NGS) techniques, including whole genome sequencing and RNA-Seq, to study the genetic basis of human diseases and the functional consequences of mutations on gene expression.
1. Lingling Shi, Yunfei Guo, Chengliang Dong, John Huddleston, Hui Yang, Xiaolu Han, Aisi Fu, Quan Li, Na Li, Siyi Gong, Katherine E. Lintner, Qiong Ding, Zou Wang, Jiang Hu, Depeng Wang, Feng Wang, Lin Wang, Gholson J. Lyon, Yongtao Guan, Yufeng Shen, Oleg V. Evgrafov, James A. Knowles, Francoise Thibaud-Nissen, Valerie Schneider, Chack-Yung Yu, Libing Zhou1,Evan E. Eichler, Kwok-Fai So, & Kai Wang. Long-read sequencing and de novo assembly of a Chinese genome. NATURE COMMUNICATIONS. 2016, dx.doi.org/10.1038/NCOMMS120652
2. Lingling Shi, Bingxiao Li, Yonglan Huang, Xueying Ling, Tianyun Liu, Gholson J Lyon, Anding Xu, Kai Wang.“Genotype-first” approaches on a curious case of idiopathic progressive cognitive decline. BMC Med Genomics. 2014, 3;7(1):66.Doi: 10.1186/s12920-014-0066-9.
3. Ling-ling Shi, Xiao Chang, Peilin Zhang, Macello Coba, Wange Lu, Kai Wang. The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells.Human Molecular Genetics. 2013, doi: 10.1093.
4. Ling-ling Shi*, Xu Zhang*, Ryan Golhar, Frederick G Otieno, Mingze He, Cuiping Hou, Cecelia Kim, Brendan Keating, Kai Wang, Hakon Hakonarson. Whole-genome sequencing in an autism multiplex family. Molecular Autism.2013, 4:8 (*: First author) .
5. Liyun Zeng*, Peilin Zhang*, Ling-ling Shi*, Vicky Yamamoto, Wange Lu, Kai Wang. Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models. PLoS ONE. 2013, 8: e59685 (*co-first author).
6. Ling-ling Shi, Fu-ping Liu, De-wen Wang. Transplantation of human umbilical cord blood mesenchymal stem cells improves outcome of rat model of acute hepatic necrosis.Am J Med Sci. 2011, 342(3):212-217 .
7. Gao F, Shi L, Russin J, Zeng L, Chang X, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Mack WJ, Wang K. DNA Methylation in the Malignant Transformation of Meningiomas. PLoS ONE.2013, 8:e54114.
8. Gao F, Ling C, Shi L, Commins D, Zada G, Mack W, Wang K. Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma. British Journal of Cancer. 2013, doi: 10.1038/bjc.2013.395.
