RESEARCH DESCRIPTION

Focused on elucidating the molecular mechanism of neurodegenerative disease including Huntington’s and ALS/FTLD Disease using non-human primate and mouse models, such as the function of neuronal and non-neuronal aging-associated gene on misfolded proteins degradation; comparation analysis of the pathological  mechanism and evaluation of therapeutic effect of potential chemical during species.

DEGREES & EDUCATION

2015-2019    Postdoc.  Emory University. Human Genetics Department

2012-2015    Assistant Researcher.  CAS.   Institute of Genetics and Developmental Biology

2009-2012    Ph.D.    Fudan University. Biochemisty and Molecular Biology

RECENT SELECTED PUBLICATIONS

(^#Cor-first and *Cor-responding authors)

1. Peng Yin, Shihua Li, Xiao-Jiang Li ,Weili Yang. New pathogenic insights from large animal models of neurodegenerative diseases. Protein & Cell (2022) 

2. Peng Yin，Dazhang Bai, Fuyu  Deng, Chen Zhang, Qingqing Jia, Longhong  Zhu, Laiqiang Chen, Bang Li, Xiangyu  Guo, Jianmeng Ye,  Zhiqiang Tan, Lu Wang, Shihua Li*,  Xiao-Jiang Li*. SQSTM1 mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy (2021). 

3. Peng Yin*，Dazhang Bai,  Longhong  Zhu, Fuyu  Deng,  Xiangyu  Guo, Bang Li, Laiqiang Chen, Shihua Li*,  Xiao-Jiang Li* .Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system. Experimental Neurology (2021). 

4. Dazhang Bai#,  Peng Yin#*, Yiran Zhang,  Fengwei Sun,  Laiqiang Chen,  Li Lin, Sen Yan,  Shihua Li,  Xiao-Jiang Li*. Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Human Molecular Genetics (2021). 

5. Yin, P.*, Liu, Q., Pan, Y., Yang, W., Yang, S., Wei, W., Chen, X., Hong, Y., Bai, D., Li, X., and Li, S.*. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. EMBO Reports (2020).

6. Yin, P., Guo, X., Yang, W., Yan, S., Yang, S., Zhao, T., Sun, Q., Liu, Y.*, Li, S.*, and Li, X.*. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathologica (2019). 

7. Yin, P., Tu, Z., Yin, A., Zhao, T., Yan, S., Guo, X., Chang, R., Zhang, L., Hong, Y., Huang, X., Zhou, J., Wang, Y., Li, S., and Li, X.*, Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Human Molecular Genetics (2015). 

8. Yin P, Zhao C, Li Z, Mei C, Yao W, Qi J, Wang L, Shi Y, Qiu S, Fan J, Zha X. Sp1 Is Involved  in  Regulation  of  Cystathionine  γ-lyase  gene  Expression  and  Biological Function by PI3K/Akt pathway. Cellular Signalling. (2012)