Prof. Wenliang Lei
leiwenliang@jnu.edu.cn
86-020-85220870
leiwenliang@jnu.edu.cn
86-020-85220870
Dr. Lei’s research interests include: (1) the cellular mechanisms of synaptic development and plasticity, (2) the development of non-human primate models for neurodegenerative disorders, (3) the mechanisms and applications of in vivo neuroregeneration in CNS diseases and injuries, and (4) the application of cutting-edge bioimaging technologies. Recently Dr. Lei’s lab mainly focuses on the (1) in vivo two-photon live imaging of direct astrocyte-to-neuron conversion, (2) the development of a rhesus monkey model with Alzheimer’s-like pathology induced by hippocampal overexpression of human tau, and (3) in vivo neuroregeneration-based gene therapies for Alzheimer’s diseases and Amyotrophic lateral sclerosis (ALS).
Bachelor in life sciences, Nankai University, 2002-2006
PhD in neurobiology, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2006-2012
Postdoc Fellow, Emory University, 2013-2018
(* First and # Corresponding authors)
1. Wang, QS., Li, W., Lei, WL.*, Chen, WY., Zheng, JJ., Xiang, ZQ., Liu, MH., He, Q., Xu, L., Li, ZF., Wang, T., Wu, Z., Chen, G. (2021) In situ neuroregeneration: frontiers and therapeutic prospects. Scientia Sinica Vitae. 2021, 51, doi: 10.1360/SSV-2021-00 24.
2. Xiang, ZQ., Xu, L., Liu, MH., Wang, QS., Li, W., Lei, WL.#, Chen, G. (2021) Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex. Neural Regeneration Research. 16(4):750-756. (co-corresponding author)
3. Lei, WL.*, Li, W., Ge, LJ., Chen, G. (2019) Non-engineered and engineered adult neurogenesis in mammalian brains. Frontiers in Neuroscience. 13: 131. (co-first and co-corresponding author)
4. Omotade, OF., Rui, YF., Lei, WL., Yu, K., Hartzell, HC., Fowler, VM., Zheng, JQ. (2018) Tropomodulin isoform-specific regulation of dendrite development and synapse formation. The Journal of Neuroscience. 38: 10271-10285.
5. Lei, WL.*, Myers, KR., Rui, YF., Hladyshau, S., Tsygankov, D., and Zheng, JQ. (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. The Journal of Cell Biology. 216: 2551-2564.
6. Lei, WL.*, Omotade, OF., Myers, KR., and Zheng, JQ. (2016) Actin cytoskeleton in dendritic spine development and plasticity. Current Opinion in Neurobiology. 39: 86-92.
7. Deng, CY., Lei, WL., Xu, XH., Ju, XC., Liu, Y., and Luo, ZG. (2014) Jip1 mediates anterograde transport of Rab10 cargos during neuronal polarization. The Journal of Neuroscience. 34: 1710-1723.
8. Lei, WL.*, Xing, SG., Deng CY., Ju XC., Jiang XY., and Luo, ZG. (2012) Laminin/ beta1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization. Cell Research. 22: 954-972.
9. Wang, J., Fu, XQ., Lei, WL., Wang, T., Sheng, AL., and Luo, ZG. (2010) Nuclear factor κB controls acetylcholine receptor clustering at the neuromuscular junction. The Journal of Neuroscience. 30: 11104-11113.
10. Wang, J., Ruan, NJ., Qian, L., Lei, WL., Chen, F., and Luo, ZG. (2008) Wnt/ beta-catenin signaling suppresses rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction. The Journal of Biological Chemistry. 283: 21668-21675.
