Prof. Sen Yan
231yansen@jnu.edu.cn
86-020-85227086
231yansen@jnu.edu.cn
86-020-85227086
Sen Yan, Ph.D., Professor, Investigator of GHMICR, honored as the National Science Fund for Excellent Young Scholars,Young Pearl River Scholar, The main interest is to understand the molecular mechanical of neurodegeneration disease such as HD, AD, PD, ALS. 1. Currently, we focus on Huntington’s disease (HD) and Alzheimer disease which might caused by misfolded protein. Embryonic development and gene modification in embryo. 2. Using large animal models are extremely valuable to help them understand the pathogenesis of neurodegenerative disorders and to find treatments for them. 3. Gene therapy for large animal model of neurodegenerative diseases. Some work were published in journal of Cell，PNAS，Human Molecular Genetics，Molecular Neurodegeneration，Plos genetics. The goal of the studies is to provide mechanistic insight into the pathogenesis of neurodegeneration caused by misfolding protein and to help develop effective therapeutic strategies.
Bachelor of Science , Jilin University, 2008
Visiting Ph.D student, Emory University,2011-2013
Ph.D., Jilin University, 2013
2014-2016, Postdoc Fellow, Institute of genetics and developmental biology, Chinese Academy of Sciences.
2016-2018, Associate Professor, Guangdong-Hongkong Macau Institute of CNS Regeneration,
Jinan University, Guangzhou, China.
2019-Present, Professor, Guangdong-Hongkong Macau Institute of CNS Regeneration,
Jinan University, Guangzhou, China.
(* First and # Corresponding authors)
Review articles
1. Huang C, Yan S*, Zhang Z*. Maintaining the balance of TDP-43, mitochondria,
and autophagy: a promising therapeutic strategy for neurodegenerative diseases. Transl Neurodegener. 2020 Oct 30;9(1):40. pii: 10.1186/s40035-020-00219-w. doi: 10.1186/s40035-020-00219-w.
2. Yan S, Tu Z, Li S, Li XJ. Use of CRISPR/Cas9 to model brain diseases. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb2;81:488-492.doi:10.1016/j.pnpbp. 2017.04.003. Epub 2017 Apr 6. Review.
Original articles
1. Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai
C,Yang H, Li L, Liu Q, Shi H, Xu G, Zhao H, Wei H, Pei Z, Li S, Lai L, Li XJ. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. 2018 May3;173(4):989-1002.e13. doi: 10.1016/j.cell.2018.03.005.
2. Huang C#, Li J#, Zhang G, Lin Y, Li C, Zheng X, Song X, Han B, Guo B, Tu Z, Zhang J, Sun Y, Wang Y, Zhang Z*, Yan S*. TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS. Hum Mol Genet. 2021 Jul 28;30(16):1484-1496.
3. Zhang XY, Li J, Li CJ, Lin YQ, Huang CH, Zheng X, Song XC, Tu ZC, Li XJ*, Yan S*. Differential development and electrophysiological activity in cultured
cortical neurons from the mouse and cynomolgus monkey. Neural Regen Res. 2021Dec;16(12):2446-2452.
4. Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S, Li XJ*, Tdp-43 Causes differential pathology in neuronal versus glial cells in the mouse brain, Hum Mol Genet. 23(10):2678-93,2014.
5. Wang GH#, Yang HQ#, Yan S# , Wang CE, Liu XD,Li XJ* and Lai LX*，Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain, Molecular Neurodegeneration. 2015 Sep 3;10:42.
6. Tu, Z#.; Yang, W#.; Yan, S#.; Yin, A.; Gao, J.; Liu, X.; Zheng, Y.; Zheng, J.; Li,Z.; Yang, S.; Li, S.; Guo, X.; Li, X. J., Promoting Cas9 degradation reducesmosaic mutations in non-human primate embryos. Scientific reports. 2017, 7,42081.
7. Yan S, Song H, Pang D, Zou Q, Li L, Yan Q, Fan N, Zhao X, Yu H, Li Z, Wang H, Gao F, Ouyang H, Lai L*, Expression of plant sweet protein brazzein in the milk of transgenic mice, PLoS One . 8,e76769,2013.
