Prof. Ying Xu
xuying@jnu.edu.cn
86-020-85227086
xuying@jnu.edu.cn
86-020-85227086
Prof. Ying Xu’s laboratory is currently focus on the treatment of retinal degeneration and related mechanisms, using animal models of rodent and non-human primate, as well as cell lines. Her research interest include:
(1) Explore strategies to protect degenerated retina in various animal models and restore vision.
(2) Explore the underlying mechanisms of photoreceptor degeneration.
(3) Explore the retinal degeneration in brain degenerated diseases like Alzheimer’s disease.
B. S. in Biophysics and Physiology, Peking University, Beijing, China, 1997
Ph. D. in Biophysics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2002
Postdoctoral Researcher, University of Pennsylvania, Philadelphia, US, 2002-2007
Research Associate, University of Pennsylvania, Philadelphia, US, 2007-2009
Associate Professor, Jinan University, Guangzhou, China, 2010-2018
Professor, Jinan University, Guangzhou, China, 2018-present
(# Corresponding authors)
1. Liu XB, Liu F, Liang YY, Yin G, Zhang HJ, Mi XS, Zhang ZJ, So KF, Li A#, Xu Y#.Luteolin delays photoreceptor degeneration in a mouse model of retinitispigmentosa.Neural Regen Res. 2021 Oct;16(10):2109-2120. doi: 10.4103/1673-5374.303537.
2. Liu F, Liu X, Zhou Y, Yu Y, Wang K, Zhou Z, Gao H, So KF, Vardi N, Xu Y#. Wolfberry‐derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways. J Neurochem. 2021 Sep;158(5):1131-1150. doi: 10.1111/jnc.15472.
3. 3. Zhang M, Zhong L, Han X, Xiong G, Xu D, Zhang S, Cheng H, Chiu K#, Xu Y#. Brain and retinal abnormalities in the 5xFAD mouse model of Alzheimer's disease at early stages. Front Neurosci. 2021 Jul 23;15:681831. doi:10.3389/fnins.2021.681831
4. Xiang Z, Bao Y, Zhang J, Liu C, Xu D, Liu F, Chen H, He L, Ramakrishna S, Zhang Z, Vardi N, Xu Y#. Inhibition of non-NMDA ionotropic glutamate receptors delays the retinal degeneration in rd10 mouse. Neuropharmacology.2018,139:137-149. doi: 10.1016/j.neuropharm.2018.06.027.
5. Zhang Y, Bao Y, Qiu W, Peng L, Fang L, Xu Y#, Yang H#. Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis. Exp Eye Res. 2018 Jun 18;175:124-132. doi: 10.1016/j.exer.2018.06.011.
6. Liu F, Zhang J, Xiang Z, Xu D, So KF, Vardi N, Xu Y#. Lycium barbarum polysaccharides protect retina in rd1 mice during photoreceptors degeneration. IOVS. 2018 Jan 1;59(1):597-611.
7. Zhang J, Xu D, Ouyang H, Hu S, Li A, Luo H#, Xu Y#. Neuroprotective effects of methyl 3,4 dihydroxybenzoate in a mouse model of retinitis pigmentosa. Exp Eye Res. 2017 Sep;162:86-96.
8. Luo X, Yu Y, Xiang Z, Wu H, Ramakrishna S, Wang Y, So KF, Zhang Z#, Xu Y#. Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity.J Neurochem. 2017, 141(3):373-386. doi: 10.1111/jnc.13970.
9. Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y#, Zhou L#. Frizzled3 shapes the development of retinal rod bipolar cells. IOVS, 2016 May 1;57(6):2788-96.
10.Xu Y#, Dhingra A, Fina ME, Koike C, Furukawa T, Vardi N. mGluR6 deletion renders the TRPM1 channel in retina inactive. J Neurophysiol. 2012 Feb; 107(3):948-57.
11. For more publications, please see records on orchid：https://orcid.org/0000-0002-9987-2057
