Dr. Xiangyu Guo
guosapphire@jnu.edu.cn
86-020-85227086
guosapphire@jnu.edu.cn
86-020-85227086
There is currently no way to reverse or delay the onset and progression of the neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, which not only impose a heavy economic and emotional burden to the patient's family, but also brings more and more severe challenges to the social medical care system. Our research group is committed to expanding knowledge on early diagnosis and intervention for neurodegenerative diseases via variety of tool such as gene editing, molecular genetics, molecular pathology, molecular imaging (ultrasound, MRI, PET) and behavioral analysis, finally promote clinical translational research. Our current primary research directions focus on:
1. Molecular mechanism of Alzheimer's disease pathology;
2. Generation of novel non-human primate (monkey) model of Alzheimer's disease;
3. Generation of novel non-human primate (monkey) model of Parkinson's disease;
4. Pathological mechanisms of Huntington's disease in early development stage.
Bachelor, Henan Normal University, 2004
PhD, Kunming Institute of Zoology, Chinese Academy of Sciences, 2011
Postdoc Fellow, Emory University, 2012
Postdoc Fellow, Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, 2012-2016
(1) Zhuchi Tu; Weili Yang; Sen Yan; Xiangyu Guo; Xiao-Jiang Li; CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases, Molecular neurodegeneration, 2015, 10: 35
(2) Xiangyu Guo; Xiao-Jiang Li; Targeted genome editing in primate embryos,Cell Research, 2015, 25(7): 767-8
(3) Zhuchi Tu; Weili Yang; Sen Yan; An Yin; Jinquan Gao; Xudong Liu; Yinghui Zheng; Jiezhao Zheng; Zhujun Li; Su Yang; Shihua Li; Xiangyu Guo; Xiao-jiang Li; Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos., Sci Rep., 2017, 7: 42081
(4) Niu Y, Guo XY, Chen YC, Wang CE, Gao JQ, Yang WL, Kang Y, Si W, Wang H, Yang S-H, Li SH, Ji WZ, Li X-J. Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Hum Mol Genet 24(8):2308-17, 2015.
(5) Jin, L., Guo, X., Ji, S., Ji, W., and Sun, A. (2011). Demonstration of expression of hepatic stellate cell markers in cells from liver epithelial progenitor cells of rhesus monkey. Liver Int 31, 744-746.
(6) Weili Yang; Xiangyu Guo; Zhuchi Tu; Xiusheng Chen; Rui Han; Yanting Liu; Sen Yan; Qi Wang; Zhifu Wang; Xianxian Zhao; Yunpeng Zhang; Xin Xiong; Huiming Yang; Peng Yi; Huida Wan; Xingxing Chen; Jifeng Guo; Xiao-Xin Yan; Lujian Liao; Shihua Li; Xiao-Jiang Li ; PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis, Protein&Cell, 2021. 13(1): 26-46 (co-author)
(7) Yin Peng; Guo Xiangyu; Yang Weili; Yan Sen; Yang Su; Zhao Ting; Sun Qiang; Liu Yunbo; Li Shihua; Li Xiao Jiang ; Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains., Acta neuropathologica, 2019, 137(6): 919-937 (co-author)
(8) Niu, Y., Yu, Y., Bernat, A., Yang, S., He, X., Guo, X., Chen, D., Chen, Y., Ji, S., Si, W., Lv, Y., Tan, T., Wei, Q., Wang, H., Shi, L., Guan, J., Zhu, X., Afanassieff, M., Savatier, P., Zhang, K., Zhou, Q., and Ji, W. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 107, 17663-17667. (co-author)
